What’s the best way to handle being away on vacation?

Brad Feld (Managing Director at Foundry Group)
How To Deal With Email After A Long Vacation – Feld Thoughts

Here is my vacation reminder from that trip: I’m on vacation and completely off the grid until 12/8/14. I will not be reading this email. When I return, I’m archiving everything and starting with an empty inbox. If this is urgent and needs to be dealt with by someone before 12/8, please send it to my assistant. She’ll make sure it gets to the right person. If you want me to see it, please send it again after 12/8.

David Jackson (Founder, Seeking Alpha)
Is this the key to work-life balance? | A Founder’s Notebook

When you return [from vacation], reply to every email you received with a standard reply: “You sent this email when I was on vacation. If it’s still relevant and you require action from me, please send me an update. ”